Daniel Spoon, MD is a doctor in Missoula, Montana who specializes in Interventional Cardiology.Daniel B. Spoon M.D.

 

Present Academic Rank and Position

Cardiology Fellow, Division of Cardiology, Mayo Clinic, Rochester MN
Assistant Professor of Medicine, Mayo Clinic College of Medicine

Fellowship

7/2011- 6/2015 Mayo Clinic College of Medicine
Rochester, MN
NIH T32 Cardiology Fellow

7/2015-7/2016 Mayo Clinic College of Medicine
Rochester, MN
Interventional Cardiology Fellow

Board Certification

2011 American Board of Internal Medicine – Internal Medicine (2011-2021)
2015 American Board of Internal Medicine – Cardiovascular Diseases (2015-2025)

Medical Licensure

Minnesota board of medical practice 2009-Present

Honors/Awards

College

Rocky Mountain College
• Received Full Athletic Scholarship (Basketball) 1999, 2000

University of Notre Dame
• Graduated Magma Cum Laude
• Awarded Notre Dame Club of Montana Scholarship
• Selected for Alpha Epsilon Delta (Pre-Med Honors Society)

Medical School

• Awarded a 4 year tuition scholarship to Mayo Medical School (2003-2007)

• Young Investigator award – Cardiology and Cardiac Surgery Basic Science
(1st Place)- American Academy of Pediatrics 2004 National Conference and Exhibition
– First Medical Student to win the award in the competitions 40 year history

Residency

• Surgical Intern of the Year Award (2007-2008)- Department of Plastic Surgery Brigham and Women’s Hospital, Boston MA

• Mayo Clinic Dept. of Internal Medicine ACE Award 2010
– Peer selected, given to 3 residents per class, most
exhibiting “Attitude, Commitment, and Excellence”

Educational Activities

A. Curriculum/ Course Development and Coordination

• Co-Chair Harrison’s Club for Internal Medicine Residents (2009-2010)
– Organized twice monthly review sessions for Mayo residents. Selected review questions, assigned reading, promoted attendance/participation by fellow residents

B. Teaching Activities

• Cardiac Catheterization Grand Rounds- “Mayo Program in Biologic Heart Valve Development- The Approaches and Challenges Ahead.”
– October 3, 2013
– Mayo Clinic, Rochester MN

• Cardiology Grand Rounds- “Long term mortality after PCI: Insights from 7000 deaths over 20 years.”
– July 12, 2013
– Mayo Clinic, Rochester MN

• Cardiac Catheterization Grand Rounds- “The Only Certainty in Life is Death…Based upon Retrospective Cohort Data.”
– January 10, 2013
– Mayo Clinic, Rochester MN

• Cardiovascular Research Grand Rounds- “Mayo Program in Biologic Heart Valve Development”
– February 16, 2012
– Mayo Clinic, Rochester MN

• Cardiac Catheterization Grand Rounds- “Mayo Program in Biologic Heart Valve Development”
– March 15, 2012
– Mayo Clinic, Rochester MN

• First International Biologic Valve Symposium- “Challenges for the Translation of Engineered Tissue Valves: From Bench to Bedside”
– September 12, 2012
– Mayo Clinic, Rochester MN

Research Activities

1. “Tissue Engineering of Human Heart Valves” Developing methods of fabrication (decellularization, 3D printing, electrospinning) and recellularization of cardiac semilunar valves.
Mentor: Robert D. Simari M.D.

2. “Evaluation of Myeloid Cells (CD14+) Expressing an Osteogenic Phenotype (OCN+) and their Role in Vascular/Valvular Calcification”
Mentors: Robert D. Simari M.D, Amir Lerman M.D., Sundeep Khosla M.D.

3. “Function of Patient Specific iPSC-Derived Endothelium”
Mentor: Robert D. Simari M.D

Research Trials

Principal Investigator
Xience Short DAPT
DalGene

Sub- Investigator
Absorb

Research Grants Awarded

NIH T32 Grant – 2 years of funding for basic science research during cardiology fellowship (2011-2013)

Asper Foundation Grant – 250,000$ over two years (2012-2014)
– Myofibroblast diversity in tissue engineering

Grainger Foundation – Regenerative Medicine – 250,000$ over two years (2012-2014)
– Computer-aided design and 3D printing of biological heart valves

Patents

1. Device and Methods for Self-Centering a Guide Catheter, 7/22/13
Patent Application #: 61/856,910 – (patent pending)

Publications

1. Original Articles – Published/ In Press

1. Spoon JN, Nkomo VT, Suri RM, Pislaru SV, Spoon DB, Michelena HI, Sarano ME, Malouf JF. Mechanisms of Mitral Valve Dysfunction Following Mitral Valve Repair for Degenerative Disease. JACC Cardiovasc Imaging. 2015 Oct;8(10):1223-7.

2. Helder MR, Hennessy RS, Spoon DB, Tefft BJ, Witt TA, Marler RJ, Pislaru SV, Simari RD, Stulak JM, Lerman A. Low-Dose Gamma Irradiation of Decellularized Heart Valves Results in Tissue Injury In Vitro and In Vivo. Ann Thorac Surg. 2015 Oct 7. pii: S0003-4975(15)01340-5.

3. Spoon DB, Lennon RJ, Psaltis PJ, Prasad A, Holmes DR Jr, Lerman A, Rihal CS, Gersh BJ, Ting HH, Singh M, Gulati R. Prediction of Cardiac and Non-cardiac Mortality Following Percutaneous Coronary Intervention. Circ Cardiovasc Interv. 2015 Sep;8(9).

4. Collin J, Gössl M, Matsuo Y, Cilluffo R, Flammer AJ, Loeffler D, Lennon RJ, Simari RD, Spoon DB, Erbel R, Lerman LO, Khosla S, Lerman A. Osteogenic Monocytes within the Coronary Circulation and their Association with Plaque Vulnerability in Patients with Early Atherosclerosis. In Press – International Journal of Cardiology.

5. Jana S, Simari RD, Spoon DB, Lerman A. Drug delivery in aortic valve tissue engineering. J Control Release. 2014 Oct 22;196C:307-323.

6. Perez Botero J, Spoon DB, Patnaik MS, Ashrani AA, Trousdale RT, Pruthi RK. Incidence of symptomatic venous thromboembolism in patients with hemophilia undergoing joint replacement surgery: A retrospective study. Thromb Res. 2014 Nov 18.

7. Psaltis PJ, Spoon DB, Wong DTL, Gulati R. An Update on Stem Cell Therapies for Acute Coronary Syndrome. Curr Cardiol Rep. 2014 Sep;16(9):526.

8. Psaltis PJ, Puranik A, Spoon DB, Chue CD, Hoffman SJ, Witt TA, Delacroix S, Kleppe LS, Mueske CS, Pan SC, Gulati R, Simari RD. Characterization of a resident population of adventitial macrophage progenitor cells in postnatal vasculature. Circ Res. 2014 Jun 6.

9. Simari RD, Pepine CJ, Traverse JH, Henry TD, Bolli R, Spoon DB, Yeh E, Hare JM, Schulman I, Anderson RD, Lambert C, Sayre SL, Taylor DA, Ebert RF, Moye LA. Bone Marrow Mononuclear Cell Therapy for Acute Myocardial Infraction: A Perspective from the CCTRN. Circ Research. May 9, 2014, 114: 1564-1568.

10. Jana S, Tefft BJ, Spoon DB, Simari RD. Scaffolds for tissue engineering of cardiac valves. Acta Biomater. 2014 Jul;10(7):2877-93.

11. Spoon DB, Psaltis PJ, Holmes DR, Gersh BJ, Rihal CS, Lennon RJ, Moussa ID, Simari RD, Gulati R. Trends in cause of death after percutaneous coronary intervention. Circulation. 2014 Mar 25;129(12):1286-94.

12. Psaltis PJ, Spoon DB, Wong DTL. Utility of Mesenchymal Stromal Cells for Myocardial Infarction – Transitioning from Bench to Bedside. Minerva Cardioangiol. 2013 Dec;61(6):639-63.

13. Spoon DB, Malouf JF, Spoon JN, Nkomo VT, Sorajja P, Mankad S, Lennon RJ, Cabalka A, Rihal CS. Mitral Paravalvular Leak: Description and Assessment of a Novel Anatomical Method of Localization. J Am Coll Cardiol Img. 2013; 6(11):1212-1214.

14. Kunkala MR, Schaff HV, Burkhart H, Sandhu G, Spoon DB, Ommen SR, Sorajja P, Dearani JA. Outcome of Repair of Myocardial Bridging at the Time of Septal Myectomy. Ann Thorac Surg. 2014 Jan;97(1):118-23.

15. Spoon DB, Tefft BJ, Lerman A, Simari RD. Challenges of Biological Valve Development. Interv Cardiol (2013) 5(3), 319-334.

16. Spoon DB, Rubinshtein R, Psaltis PJ, Sandhu GS, Rihal CS, Lerman A. Comparison between 3 Dimensional Angiographic Reconstruction and Intervascular Ultrasound – Imagining of the Left Main Coronary Artery. Catheter Cardiovasc Interv. 2013 Feb 21.

17. Traverse JH, Henry TD, Pepine CJ, Willerson JT, Zhao DX, Ellis SG, Forder JR, Anderson RD, Hatzopoulos AK, Penn MS, Perin EC, Chambers J, Baran KW, Raveendran G, Lambert C, Lerman A, Simon DI, Vaughan DE, Lai D, Gee AP, Taylor DA, Cogle CR, Thomas JD, Olson RE, Bowman S, Francescon J, Geither C, Handberg E, Kappenman C, Westbrook L, Piller LB, Simpson LM, Baraniuk S, Loghin C, Aguilar D, Richman S, Zierold C, Spoon DB, Bettencourt J, Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD; for the Cardiovascular Cell Therapy Research Network (CCTRN). Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction: The TIME Randomized Trial. JAMA. 2012 Dec 12;308(22):2380-9.

18. Hoffman SJ, Psaltis PJ, Clark KJ, Spoon DB, Chue CD, Ekker SC, Simari RD. An In Vivo Method to Quantify Lymphangiogenesis in Zebrafish. PLoS ONE 7(9): e45240. 2012.

19. Spoon DB, Orszulak TA, Edell ES, Li Z, Nishimura RA. Severe Aortic Stenosis and Chronic Obstructive Pulmonary Disease: What is the Risk of Aortic Valve Replacement in the Modern Surgical Era? J Heart Valve Dis. 2012;21:314-319.

20. Psaltis PJ, Harbuzariu A, Delacroix S, Witt T, Holroyd E, Spoon DB, Hoffman S, Kleppe L, Mueske C, Gulati R, Sandhu GS, Simari RD. Sca-1 Identifies a Monocyte-Predisposed Hierarchy of Hematopoietic Progenitor Cells in the Postnatal Murine Aorta. Circulation. 2012 Jan 31;125(4):592-603.

21. Rubinshtein R, Lerman A, Spoon DB, Rihal CS. Anatomic Features of the Left Main Coronary Artery and Factors Associated with its Bifurcation Angle: A 3-Dimensional Quantitative Coronary Angiographic Study. Catheter Cardiovasc Interv. 2012 Aug 1;80(2):304-9. Epub 2012 Mar 14.

22. Spoon DB, Lerman A, Prasad A, Holmes DR, Lennon R, Rihal CS. The Association of Serum Uric Acid Levels with Outcomes Following Percutaneous Coronary Intervention. J Interv Cardiol. 2010 Jun;23(3):277-83.

23. Grewal NS, Spoon DB, Kawamoto HK, Jones NF, Da Lio AL, Crisera C, Benhaim P, Bradley JP. Predictive factors in identifying subspecialty fellowship applicants who will have academic practices. Plast Reconstr Surg. 2008 Oct;122(4):1264-71; discussion 1272-3.

24. Galat DD, Ackerman DB, Spoon D, Turner NS, Shives TC. Synovial chondromatosis of the foot and ankle. Foot Ankle Int. 2008 Mar;29(3):312-7.

25. Dickinson BP, Spoon DB, Cordray TL, Lazareff J, Wasson K, Bradley JP. Correction of massive hydrocephalus and brain wound in holoprosencephaly: A case report. J Craniofac Surg. 2006 Jul;17(4):707-13.

26. Gabbay JS, Heller JB, Mitchell SA, Zuk PA, Spoon DB, Wasson KL, Jarrahy R, Benhaim P, Bradley JP. Osteogenic Potentiation of Human Adipose–Derived Stem Cells in a 3-Dimensional Matrix. Ann Plast Surg. 2006 Jul;57(1):89-93.

27. Gabbay JS, Heller J, Spoon DB, Mooney M, Acarturk O, Askari M, Wasson KL, Bradley JP. Noggin Under expression and Runx-2 Overexpression in a Craniosynostosis Rabbit Model. Ann Plast Surg. 2006 Mar; 56(3):306-11.

28. Tester DJ, Spoon DB, Valdivia HH, Makielski JC, Ackerman MJ. Targeted Mutational Analysis of the RyR2-encoded cardiac ryanodine receptor in Sudden Unexplained Death: a Molecular Autopsy of 49 Medical Examiner/ Coroner’s Cases. Mayo Clin Proc. 2004 Nov; 79(11): 1380-1384 *Co-equal first Author with David J. Tester.

2. Original Articles – Under Review/ In Preparation

1. Herrmann J, Singh M, Lennon R, Spoon DB, Gersh BJ, Mathew V, Gulati R. Trends in cause-specific mortality in patients with peripheral arterial disease undergoing percutaneous coronary intervention. [Under Review]

2. Spoon DB, Psaltis PJ, Roforth MM, Hoffman SJ, Witt TA, Puranik AS, Peterson JM, Mueske CS, Khosla S, Lerman A, Simari RD. Osteocalcin Expressing Myeloid Cells Generate Vascular Calcification in a Paracrine Manner. [In Preparation]

3. Spoon DB, Jama A, Conrotto F, Lennon R, Gulati R, Sandhu GS, Eeckhout E, Rihal CS, Bell M, Lerman A. Imagining of the left main coronary artery post intervention with IVUS and three-dimensional angiographic reconstruction: A comparison study. [In Preparation]

4. Spoon DB, Psaltis PJ, Kidd S, Prasad A, Lennon RJ, Singh M, Gulati R. Outcomes after Percutaneous Coronary Intervention in Patients with Thrombocytopenia. [In Preparation]

5. Spoon DB, Singh IM, Lennon RJ, Singh M, Holmes DR, Lerman A, Prasad A, Rihal CS. Clinical Outcomes of Triple Antithrombotic Therapy Versus Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention. [In Preparation]

Presentations at National and International Meetings

1. Spoon DB. PCI for Mortality in the Real World. Invited Faculty – Midwest Cardiovascular Forum – Controversies in Cardiovascular Disease. Minneapolis, MN, May 17, 2014.

2. Spoon DB, Kollengode A, Konz BA, Pandit A, Ou NN, Barsness GW, Hackler PM, Bresnahan JF, Holmen JL, Levy MS, Fortuin FD, Birchem SK, Bell MR, Askew JW, Sandhu GS. Standardized non-ST elevation myocardial infarction care process model improves compliance with guidelines. Selected for a poster presentation at The Society for Cardiovascular Angiographic Interventions (SCAI), May 2014, Las Vegas, NV.

3. Spoon DB, Singh M, Lennon RJ, Rihal CS, Gulati R. Risk Models for the prediction of Cardiac and Non-cardiac Mortality Following Percutaneous Coronary Intervention. Selected for an Oral presentation at American College of Cardiology/I2 Summit March 2013, Washington DC.

4. Spoon DB, Psaltis PJ, Holmes DR, Gersh BJ, Rihal CS, Lennon RJ, Moussa ID, Simari RD, Gulati R. Trends in Cause of Long-Term Death after Percutaneous Coronary Intervention. Selected for a poster presentation at the American Heart Association Scientific Sessions 2013 National Conference and Exhibitions, November 2013, Dallas, TX.

5. Spoon DB. 25 Years of Interventional Innovation: Novel Therapies and the “Emerging” device concepts for 2013. The Next Interventional Innovation Breakthroughs – 3D Bioprinting: The Unlimited Potential of Automated Tissue Engineering Processes. Invited Faculty – Transcatheter Cardiovascular Therapeutics (TCT), San Francisco, CA, October 27-November 1, 2013.

6. Spoon DB. Heart Valve Tissue Engineering: The Approaches and Challenges Ahead.
Invited Faculty – Rocky Mountain Valve Symposium – Rocky XXIII, Missoula, MT, July 25-26, 2013.

7. Spoon DB, Tefft BJ, Coffman KE, Pan S, Taylor DA, Lerman A, Simari RD. Cell Injection Initiates the Recellularization Process in Decellularized Porcine Aortic Valve Scaffolds. Selected for a Poster presentation at the Society for Biomaterials. April 2013, Boston MA.

8. Spoon DB, Psaltis PJ, Holmes DR, Gersh BJ, Lennon RJ, Moussa ID, Simari RD, Gulati R. Trends in cause of long-term death after percutaneous coronary intervention. Selected for a Poster presentation at the American College of Cardiology/I2 Summit March 2013, San Francisco CA.

9. Spoon DB, Psaltis PJ, Kidd S, Prasad A, Lennon RJ, Singh M, Gulati R. Outcomes after Percutaneous Coronary Intervention in Patients with Thrombocytopenia. Selected for a Poster presentation at the American College of Cardiology/I2 Summit March 2013, San Francisco CA.

10. Spoon DB, Psaltis PJ, Hoffman SJ, Witt TA, Lerman A, Khosla S, Simari RD. Delivery of Osteocalcin (OCN+) Expressing Myeloid Cells is Sufficient to Generate Vascular Calcification. Selected for an Oral presentation at the American Heart Association Scientific Sessions 2012 National Conference and Exhibitions, November 2012, Los Angeles, CA.

11. Spoon DB, Malouf JF, Sorajja P, Cabalka A, Mankad S, Maleszewski JJ, Rihal CS. Mitral Paravalvular Leak: Description and Assessment of a Novel Anatomical Method of Localization. Selected for a poster presentation at the American College of Cardiology/I2 Summit March 2012, Chicago IL.

12. Spoon DB, Rubinshtein R, Lerman A, Rihal CS. Comparison between 3 Dimensional Angiographic Reconstruction and Intervascular Ultrasound – Imagining of the Left Main Coronary Artery. Selected for an Oral Presentation at the Innovations in Cardiovascular Interventions Meeting, December 5-7 2010, Tel-Aviv, Israel.

13. Rubinshtein R, Lerman A, Spoon DB, Rihal CS. Relation between Clinical and Anatomic Factors and the Left Main Bifurcation Angle: A 3-Dimensional Coronary Angiographic Study. Selected for a Poster Presentation at the American Heart Association Scientific Sessions 2010 National Conference and Exhibitions, November 2010, Chicago, Il.

14. Spoon DB, Orszulak TA, Edell ES, Li Z, Nishimura RA. Severe Aortic Stenosis and Chronic Obstructive Pulmonary Disease: What is the Risk of Aortic Valve Replacement in the Modern Surgical Era? Selected for a Poster Presentation at the American Heart Association Scientific Sessions 2009 National Conference and Exhibitions, November 2009, Orlando, Fl.

15. Spoon DB, Syed FF, Berbari EF. Neisseria elongata endocarditis of a prosthetic aortic valve. Selected for a poster presentation at the Regional American College of Physicians poster event, November 2009, Rochester MN

16. Spoon DB, Lerman A, Prasad A, Holmes DR, Lennon R, Rihal CS. The Association of Serum Uric Acid Levels with Outcomes Following Percutaneous Coronary Intervention. Selected for a poster presentation at the American College of Cardiology/I2 Summit March 2009, Orlando Fl.

17. Spoon DB, Nyman MA. Enlarging Liver Mass. Selected for a presentation at the Regional American College of Physicians poster event, November 2008, Minneapolis MN

18. Spoon DB, Heller J, Gabbay J, Zuk P, Wasson KL, Bradley JP. Cranial Suture Response to Stress: Evaluation of Vascular, Osteogenic, and Apoptotic Markers in Rat Cranial Sutures. Selected for an oral presentation at the American Cleft Palate-Craniofacial Association’s national meeting April 2006, Vancouver, BC.

19. Spoon DB, Tester DJ, Valdivia HH, Makielski JC, Ackerman MJ. Targeted Mutational Analysis of the Cardiac Ryanodine Receptor (RyR2) in Sudden Unexplained Death: a Molecular Autopsy of 68 Medical Examiner/Coroner’s Cases. Selected for oral presentation at the American Heart Association Scientific Session 2004 National Conference and Exhibition, November 2004, New Orleans, LA.

20. Spoon DB, Tester DJ, Valdivia HH, Makielski JC, Ackerman MJ. Targeted Mutational Analysis of the Cardiac Ryanodine Receptor (RyR2) in Sudden Unexplained Death: a Molecular Autopsy of 68 Medical Examiner/Coroner’s Cases. Selected for oral presentation at the American Academy of Pediatrics 2004 National Conference and Exhibition, Section on Cardiology and Cardiac Surgery, October 2004, San Francisco, CA.