James T. Maddux, MD

James T. Maddux, MD

Interventional Cardiology



Specialty Interests
Structural Heart Disease
Percutaneous Valve Therapies
Intra-Cardiac Defect Closure
Chronic Total Occlusion Coronary Intervention
Alcohol Septal Ablation


Fellowship in General Cardiology at the University of Colorado Health Sciences Center, Denver, CO
Fellowship in Interventional Cardiology at the University of Colorado Health Sciences Center, Denver, CO
Chief Residency in Internal Medicine at the University of Minnesota Hospital & Clinic, Minneapolis, MN
Residency in Internal Medicine at the University of Minnesota Hospital & Clinic, Minneapolis, MN
Internship in Internal Medicine at the University of Minnesota Hospital & Clinic, Minneapolis, MN
M.D. from Jefferson Medical College at Thomas Jefferson University, Philadelphia, PA
B.A. in Biology from the University of Puget Sound, Tacoma, WA

Board Certification

American Board of Internal Medicine 1998-2008
American Board of Internal Medicine Cardiovascular Disease 2003-2013
American Board of Internal Medicine Interventional Cardiology 2005-2015

Research Trials

Principal Investigator

Reduce LAP-HF
SPIRIT Small Vessel Registry
PFO Occluder


Xience Short DAPT


Garcia JA, Agostoni P, Green NE, Maddux JT, Chen SY, Messenger JC, Casserly IP, Hansgen A, Wink O, Movassaghi B, Groves BM, Van Den Heuvel P, Verheye S, Van Langenhove G, Vermeersch P, Van den Branden F, Yeghiazarians Y, Michaels AD, Carroll JD. Rotational vs. standard coronary angiography: an image content analysis. Catheter Cardiovasc Interv 2009 May 1;73(6):753-761.

Maddux JT, Wink O, Messenger JC, Groves BM, Liao R, Strzelczyk J, Chen SY, Carroll JD. Randomized study of the safety and clinical utility of rotational angiography versus standard angiography in the diagnosis of coronary artery disease. Catheter Cardiovasc Interv 2004 Jun;62(2):167-174.

Maddux JT, Chen SYJ, Groves BM, Messenger JC, Wink O, Carroll JD. Rotational Angiography and 3D Coronary Modeling: Revolutions in the Cardiac Cath Lab. Medica Mundi 2003:47;8-14.

Green NE, Maddux JT, Burchenal JE. Coronary Angioplasty. Curr Treat Options Cardiovasc Med 2003 Feb;5(1):13-24.

Maddux JT, Carroll JD, Groves BM, Messenger JC, Tseng A, Falcone E, Burchenal JE. Optimal deployment of third-generation stents: an intravascular ultrasound assessment. Catheter Cardiovasc Interv 2002 Oct;57(2):142-147.


Maddux JT, Groves BM, Messenger JC, Chen S-Y, Liao R, Wink O, Hansgen AR, Carroll JC. Validation of 3-D Coronary Models Generated from Rotational Angiograms. Abstract Presented at The Society of Cardiac Angiography and Intervention Scientific Sessions, Boston, MA, 2003.

Maddux JT, Iskos D, Mulligan KA, McKnite SH, Peterson C, Zielinski T, Lurie KG. Vasopressin and the Nitric Oxide Donor Diethylamine/Nitric Oxide (DEA/NO) Enhance Epinephrine Efficacy During Cardiopulmonary Resuscitation. Abstract Presented at the American Heart Association Scientific Sessions, Dallas, TX, 1998.


Maddux JT, Burchenal JEB. Percutaneous Transluminal Coronary Angioplasty. eMedicine Online Textbook of Medicine. http://www.emedicine.com 2000.

Maddux JT. Cardiogenic shock. In Bristow MR, Hergott LJ (eds): Treatment Strategies In Cardiovascular Medicine. New York, NY:Pocketmedicine.com, 2002.

Maddux JT, Messenger JC. Peri-operative Myocardial Infarction and Ischemia. Surgical Decision Making, 5th Edition, 2003.

Study Related Publications

Stone GW, Midei M, Newman W, Sanz M, Hermiller JB, Williams J, Farhat N, Caputo R, Xenopoulos N, Applegate R, Gordon P, White RM, Sudhir K, Cutlip DE, Petersen JL; SPIRIT III Investigators. Randomized comparison of everolimus-eluting and paclitaxel-eluting stents: two-year clinical follow-up from the Clinical Evaluation of the Xience V Everolimus Eluting Coronary Stent System in the Treatment of Patients with de novo Native Coronary Artery Lesions (SPIRIT) III trial. Circulation 2009 Feb 10;119(5):680-686. Epub 2009 Jan 26.

Stone GW, Midei M, Newman W, Sanz M, Hermiller JB, Williams J, Farhat N, Mahaffey KW, Cutlip DE, Fitzgerald PJ, Sood P, Su X, Lansky AJ; SPIRIT III Investigators. Comparison of an everolimus-eluting stent and a paclitaxel-eluting stent in patients with coronary artery disease: a randomized trial. JAMA 2008 Apr 23;299(16):1903-1913.

Feldman T, Kar S, Rinaldi M, Fail P, Hermiller J, Smalling R, Whitlow PL, Gray W, Low R, Herrmann HC, Lim S, Foster E, Glower D; EVEREST Investigators. Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort. J Am Coll Cardiol 2009 Aug 18;54(8):686-694.

Herrmann HC, Kar S, Siegel R, Fail P, Loghin C, Lim S, Hahn R, Rogers JH, Bommer WJ, Wang A, Berke A, Lerakis S, Kramer P, Wong SC, Foster E, Glower D, Feldman T; EVEREST Investigators. Effect of percutaneous mitral repair with the MitraClip device on mitral valve area and gradient. EuroIntervention 2009 Jan;4(4):437-442.

Successful MitraClip® Therapy Results in Favorable Mitral Annular and Left Ventricular Remodeling in High Risk Surgical Patients with Functional Mitral Regurgitation. Saibal Kar; Patrick Whitlow; Wes Pedersen; Scott Lim; Robert Kipperman; Richard Smalling; Tanvir Bajwa; Howard Herrmann; John Lasala; Paul Kramer; James Maddux; Ted Feldman; Don Glower; Blase Carabello; Elyse Foster, on behalf of the EVEREST Investigators; Being presented at Transcatheter Cardiovascular Therapeutics meeting in Sept 2009.

Effect of dronedarone on cardiovascular events in atrial fibrillation. Hohnloser SH, Crijns HJ, van Eickels M, Gaudin C, Page RL, Torp-Pedersen C, Connolly SJ; ATHENA Investigators. N Engl J Med 2009 Feb 12;360(7):668-678. Erratum in: N Engl J Med 2009 Jun 4;360(23):2487.